Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study

Research continues to investigate the causality of the association of serum vitamin D with the risk and severity of COVID-19 infection. A Mendelian Randomised study was recently conducted to address causality using genetic variants that are associated with serum vitamin D as instrumental variables to represent long-term usual exposure.  Findings suggest that genetically predicted long-term vitamin D nutritional status does not causally affect susceptibility to and severity of COVID-19 infections, including severe respiratory infection and hospitalisation.  However, results do not exclude the possibility that therapeutic doses of vitamin D may be effective in preventing or treating COVID-19 infection, warranting the need for future larger randomised controlled studies to investigate potential therapeutic effects of vitamin D supplementation in the prevention and treatment of COVID-19.


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