Changes in 25-hydroxyvitamin D levels post-vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID-19 pandemic: A systematic review

Vitamin D plays an important role in regulating the calcium and phosphate levels in the human body, in addition to its role in preventing diseases, with insufficient concentrations reported as mortality risk factors.  Ethnicities with darker skin colour are reported as being at higher risk of deficiency due to a multi-gene regulatory function of the Vitamin D receptors.  This recent systematic review investigates the effect of different types of vitamin D supplementation in Black and Asian ethnicities on changes in 25(OH)D levels.

 Quick takes:

  • Oral supplementation of vitamin D increased 25(OH)D, regardless of the supplement source (vitamin D2or D3), the administered dosage, mode of delivery or duration
  • In comparison to food fortification, which reflected smaller increases, oral supplementation increased 25(OH)D to considerably adequate levels
  • Supplementation with vitamin D3 showed significantly higher increases in 25(OH)D than increases yielded from supplementation of vitamin D2. A possible explanation could be the increased ability of vitamin D3 to bind to the vitamin D receptors after the formation of 1,24,25 (OH)3 in the kidneys
  • This systematic review reflected findings from recent literature suggesting daily intake of 7000 – 10000 IU supplementation of vitamin D3 to have potential protective capacity against adverse COVID-19 outcomes
  • Supplementation of vitamin D3 in Black and Asian ethnicities could be a beneficial intervention to reduce infection mortalities

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