Summary:
- A prospective cohort study investigated the association between daily antioxidants (vitamins A, E, and C, and zinc) intakes and the incidence of CVD.
- It selected 5102 eligible adults (n = 5102) aged ≥ 30years from the participants of the Tehran lipid and glucose study with an average follow-up of 5.3 years.
- Dietary intake was assessed using a semi-quantitative food frequency questionnaire. Anthropometrics and biochemical variables were evaluated at baseline and follow-up examinations. Multivariable Cox proportional hazard regression models were used to estimate the development of CVD associated with total intakes of vitamins A, E, and C, and zinc.
- Among all food groups consumed, the main sources of dietary vitamins A, E, and C and zinc were fruits, vegetables, and legumes.
- They also found that the risk of CVD decreased from quartile 1 to quartile 4 for vitamin E intake (HR 1.00, 0.91, 0.77, and 0.57; Ptrend = 03). The association between the risk of CVD and quartiles of vitamins A, and C and zinc intake was not statistically significant.
- This study suggests an inverse association between vitamin E intake and the risk of CVD, emphasizing the potential protective role of fruit and vegetable in the prevention of CVD.
Discussion:
- The limitation of this study is that it used an FFQ for collecting dietary data which would result in recall bias.
- Besides, the calculation of dietary intake for vitamins was done by the subjects’ reports regarding food consumption, which is less reliable than assessing vitamins via urine or circulating biomarkers over time.
- In addition, it did not consider some confounders such as supplement intake and socioeconomic levels and comorbidities during follow-up in the current study.
Question to member:
Do you think increased dietary antioxidant micronutrients intake should be recommended to the Asian population to decrease CVD risk?
Reference
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